One patient still had moderate alkaline phosphatase elevations 2 years after onset.

An alkaline phosphatase stain was used as a marker for osteoblastic phenotype.

Hypophosphatasia is associated with a defect of the tissue-non-specific alkaline phosphatase gene.

Blood tests performed to investigate this finding showed low alkaline phosphatase concentrations.

The corneal opacity disappeared within a week but alkaline phosphatase remained persistently low.